Sanchez S, Masuda H, Ruffie G, Poulletier De Gannes F, et al. (2007b)

The aim of this study was to test the effect of RFR exposure on the expression of HSPs in the skin of hairless rats. Two sets of experiments were done. In the first, the right part of the rat's back was exposed or sham-exposed to RFR at 5 W/kg for 2 hours, and the animals were then immediately sacrificed and a skin biopsy taken. In the second experiment, the rats were exposed or sham-exposed at 2.5 or 5 W/kg for 2 hours a day, 5 days per week, for 12 weeks. Skin biopsies were taken within 72 hours of the last exposure.
For both sets of experiments eight animals were in each of 4 groups - cage-controls, sham-exposed, GSM-900 exposure, and GSM-1800 exposure. Two other animals were exposed to UVB radiation (400 mJ/cm²) and skin samples taken 24 hours, for positive control purposes.

Neither single nor repeated exposures altered HSP expression in rat skin. The HSPs examined were Heat-shock cognate 70, and HSP 25 and 70.


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