Finnie JW, Blumberg PC, Manavis J, Utteridge TD, et al. (2002):

This study was done as part of the study reported by Utteridge and colleagues (2002) (see "Toxicological Experiments - Cancer studies"), which attempted to replicate Repacholi's 1997 study in mice prone to lymphoma. Finnie and colleagues used the wild-type control mice that were part of the larger study. The mice were exposed to 900 MHz fields (pulse-modulated at 217 Hz) for 1 hour per day, five days per week, for two years. There were four groups of mice at increasing energy absorption levels - 0.25, 1.0, 2.0, and 4.0 W/kg. Although it is not explicitly stated in this report, one can assume from Utteridge's paper that there were 120 animals in each of the four groups. Finnie and colleagues examined the brains of all the mice who survived to the end of the 2-year study. Thus, there were 37, 39, 23, and 39 mice in the groups referred to above. In addition, they examined 38 mice who had been sham-exposed and 21 non-exposed, freely moving, cage control animals. Only those mice microscopically free of tumours or other pathological changes were subjected to detailed brain pathology examination. The brains were examined for evidence of albumin leakage from blood vessels into brain tissue. The pathologists examining the brain tissue were unaware of the exposure status of the animal being examined.

Minor leakage of albumin was found in all exposed and non-exposed groups. There was no trend to increased leakage with increasing exposure. Most of the leakage occurred from leptomeningeal blood vessels, which have no recognized blood-brain barrier.

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