Cosquer B, Vasconcelos AP, Frohlich J, Cassel JC. (2005b)

The authors carried out four experiments in this report. In the first, they verified that treatment with scopolamine hydrobromide, injected intraperitoneally, was able to alter spatial working-memory performance of rats tested in the 12-arm radial maze.

In the second, they used scopolamine methylbromide (scopolamine MBR), a form of the drug that does not easily pass the blood-brain barrier (BBB), and injected it before a 45-minute exposure to 2.45 GHz EMFs (average whole body SAR 2.0 W/kg and brain averaged SAR of 3.0 W/kg). The rats were tested in the maze within 10 minutes of the end of the exposure. Sham-exposed rats were controls. The hypothesis was that if EMF altered the BBB permeability, scopolamine MBR would enter the brain in larger amounts than in unexposed animals, and result in radial maze performance alterations. The results showed no significant difference between the expose and unexposed animals.

In the third experiment, scopolamine MBR was injected at the end of the 45-minute exposure period. This was to ensure that the drug itself was not altered by exposure to the EMFs. There were no performance alterations in the maze in the exposed group, when compared to the unexposed.

In the last experiment, rats were subjected to i-v injections of Evans Blue dye before or after EMF exposure. There was no evidence of extravasation of the dye into brain parenchyma.

The overall conclusion was that the EMFs most probably failed to disrupt the BBB.


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