Christensen HC, Schuz J, Kosteljanetz M, Skovgard H, et al. (2004):

This is the first paper published from the international case-control study of cell phones and cancer (see "Research Programs "). It reports a nationwide, population-based study of acoustic neuroma.
Between 2000 and 2002 case of acoustic neuroma were identified as they were referred to one centre in Copenhagen, Denmark. There were 141 cases, and after exclusions 106 remained in the study. Most (75%) were diagnosed by MRI, and the rest by histological examination. Two controls were selected for each case, matched to age (within 5 years) and sex. The response rate among eligible controls was 64%, and 212 entered the study. A computerized personal questionnaire was completed by face-to-face interviews. Subjects were asked detailed questions about cell phone use, and educational status. Information was obtained from Statistics Denmark about the socioeconomic status of all eligible patients and controls, so that the characteristics of the participants and the non-participants could be compared. The relative risk of acoustic neuroma among regular cell phone users was 0.90 (CI = 0.51-1.57). In addition, no association was seen between risk of acoustic neuroma and cell phone use with increasing time since first regular exposure (reflecting latency), with increasing amount of use (reflecting dose), or with amount of use during the period 5 or more years before diagnosis (reflecting both latency and dose). Tumours did not occur more frequently on the side of the head on which the phone was typically used, and the size of the tumour did not correlate with the pattern of cell phone use.This study had some advantages over other studies of patients with acoustic neuroma. It was population-based. It used face-to-face interviews, which helps obtain reliable answers to complex questions. The matched design diminished bias due to the longer exposure of controls, because their exposure was cut off at the date of diagnosis of the corresponding case. There were no differences in socioeconomic characteristics between participants and non-participants among either patients or controls.The authors concluded that their study did not show any evidence of an association between the use of cell phones and the risk of developing acoustic neuroma.
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