Sykes, PJ, et al (2001)

The authors, from Flinders University in South Australia, used a strain of mice that have a particular tendency to undergo intrachromosomal inversion events when exposed to certain agents. This refers to a situation where a chromosome breaks and one of the fragments inverts itself and reattaches to the other fragment. They examined the effects on mice of exposure to 4W/kg pulsed 900 MHz radiation for 30 minutes. Three groups were exposed on 1, 5, and 25 days respectively. The number of intrachromosomal recombination events occurring in the spleens of the animals was detected using a special staining technique. There was no significant difference between exposed mice and controls in those exposed for 1 or 5 days, but there was a significant reduction in the recombination frequency in the 25-day group. This was seen only when the control animals in all three exposure groups were combined (giving 40 in total) and compared with the 10 in the RF-exposed group in the 25-day group.

A similar reduction in recombination events can be seen with proven genotoxic agents, so that this may not be a beneficial event. The authors state that the number of animals in each treatment group was small, and replication of the experiment with a larger number is required.

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