La Regina M, Moros EG, Pickard WF, Straube WL, et al. (2003).

This study was designed "to make a direct measurement of the effect of long-term exposure to RF radiation on the development of neoplasia in rats".

Eighty male and 80 female F344 rats were placed randomly in each of three irradiation groups: the sham group received no irradiation; the FDMA group was exposed to 835.62 MHz FDMA; the CDMA group was exposed to 847.74 MHz CDMA. The animals were exposed from 6 weeks of age. They were irradiated for 4 hours per day, 5 days per week for 2 years, excluding holidays, weekends and 10 working days. They were thus exposed for 505 days out of 730 study days.
A nominal time-averaged brain SAR value was 1.3 ± 0.5 W/kg.

Twelve sham rats, 13 FDMA rats, and 9 CDMA rats were euthanized before completion of the study. There were no significant differences in survival days between the groups. Likewise there were no significant differences in final body weights.

All major organs were evaluated grossly and histologically by a pathologist blinded to the exposure status of the animal. The number of tumours, tumour types, and incidence of hyperplasia were not significantly different between irradiated and sham-exposed animals.

The authors concluded that chronic exposure to 835.62 MHz FDMA or 847.74 CDMA RF radiation had no significant effect on the incidence of spontaneous tumours in F344 rats.

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