Other Studies
- Cell Cycle Progression

The progression of cells through the cell cycle can be impaired by environmental stress. Higashikubo and colleagues (2001) examined cell cycle progression following exposure to RF fields, because "cancer is disease of impaired cell growth control, and the regulation of cell cycle progression is an essential component of this process". There was no evidence of any disturbance of the cell cycle progression in their study. In contrast, Cleary et al. (1996) found the rate of cell cycle progression to be increased following 12 hours of exposure to 2.45 GHz RFR at 5 or 25 W/kg. Capri (2004b) found that exposure to 900 MHz RFR had no effect on cell cycle phases. Takashima (2006), however, found no effect of RFR at 2.45 GHz frequency on cell proliferation at SARs up to 200 W/kg. At 200 W/kg or more cell growth and survival were affected, and the effects appeared to be thermal in nature. Lantow (2006) found no evidence of altered cell cycle kinetics in human Mono Mac 6 cells exposed to RFR from an 1800 MHz GSM-DTX signal for 12 hours. Chauhan (2007) also found no change in cell cycle kinetics in TK6, HL60, or Mono-Mac-6 cells exposed to 1.9 GHz RFR for 6 hours at 0, 1, or 10 W/kg. Buttiglione (2007) reported that short-term exposure to 900 MHz RFR affect expression of the gene Egr-1 and cell regulatory functions.

Authors
Buttiglione M, Roca L, Montemurno E, Vitiello F, et al. (2007):
Title
Radiofrequency radiation (900 MHz) induces gene expression and affects cell-cycle control in human neuroblastoma cells.
Journal
J Cell Physiol 213: 759-767.
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Authors:
Capri M, Scarcella E, Fumelli C, Bianchi E, et al. (2004b)
Title:
In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential.
Journal:
Radiation Research 162:211-218.
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Authors
Chauhan V, Mariampillai A, Kutzner BC, Wikins RC, et al. (2007)
Title
Evaluating the biological effects of intermittent 1.9 GHz pulse-modulated radiofrequency fields in a series of human-derived cell lines.
Journal
Radiat Res 167:87-93.
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Authors

Higashikubo R, Ragouzis M, Moros EG, Straube WL, et al. (2001)
Title
Radiofrequency electromagnetic fields do not alter the cell cycle progression of C3H 10T½ and U87 MG cells
Journal
Radiat Res 156:786-795
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Authors
Lantow M, Viergutz T, Weiss DG, Simko M. (2006)
Title
Comparative study of cell cycle kinetics and induction of apoptosis after exposure of human mono Mac 6 cells to radiofrequency radiation.
Journal
Radiat Res 166:539-543.
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Authors
 Lee JJ , Kwak HJ, Lee YM, Lee JW, ParkMJ, Ko YG, Cho YD, Kim N, Pack JK, Hong SI, Lee JS.  
Title
Acute radio frequency irradiation does not affect cell cycle, cellular
migration, and invasion.
Journal
Bioelectromagnetics. Ahead of print 30 May 2008.

Authors
Schrader T, Münter K, Kleine-Ostmann T,Schmid E.
Title
Spindle disturbances in human-hamster hybrid (AL) cells induced by mobile communication frequency range signals.
Journal
Bioelectromagnetics Ahead of print 30 May 2008.


Authors
Takashima Y, Hirose H, Koyama S, Suzuki Y, et al. (2006)
Title
Effects of continuous and intermittent exposure to RF fields with a wide range of SARs on cell growth, survival, and cell cycle distribution.
Journal
Bioelectromagnetics 27:392-400.
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